Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11687595 | 0.86 | KMT2A (0.57) | KMT2AMEN1NPC1RAB9ASRD5A2 | |
| SCHEMBL11688264 | 0.83 | KMT2A (0.54) | KMT2AMEN1NPC1RAB9ASRD5A2 | |
| SCHEMBL21244769 | 0.83 | MEN1 (0.55) | KMT2AMEN1NPC1RAB9ASRD5A2 | |
| SCHEMBL8942111 | 0.81 | GRIK1 (0.67) | KMT2AMEN1NPC1RAB9ACYP19A1 | |
| SCHEMBL4470968 | 0.78 | SRD5A2 (1.00) | KMT2AMEN1NPC1RAB9ASRD5A2 | |
| SCHEMBL5671185 | 0.78 | MEN1 (0.67) | KMT2AMEN1NPC1RAB9ASRD5A2 | |
| SCHEMBL11687742 | 0.78 | GRIK1 (0.63) | KMT2AMEN1CYP19A1GRIK1GRIK2 | |
| SCHEMBL17558914 | 0.77 | NPC1 (0.66) | KMT2AMEN1NPC1RAB9ASRD5A2 | |
| SCHEMBL5670247 | 0.77 | MEN1 (0.66) | KMT2AMEN1NPC1RAB9ASRD5A2 | |
| SCHEMBL4020908 | 0.77 | MEN1 (0.66) | KMT2AMEN1NPC1RAB9ASRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019153007-A2 | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE BOARO OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2019-08-08 | — | — | WO | disclosed |