⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038899 | 0.79 | — | — | |
| SCHEMBL5943347 | 0.76 | — | — | |
| SCHEMBL16111087 | 0.76 | — | — | |
| SCHEMBL1470440 | 0.69 | — | — | |
| SCHEMBL10814530 | 0.66 | — | — | |
| SCHEMBL3415838 | 0.65 | — | — | |
| SCHEMBL3942251 | 0.65 | — | — | |
| SCHEMBL3929885 | 0.65 | — | — | |
| SCHEMBL15403433 | 0.64 | — | — | |
| SCHEMBL5059018 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240173321-A1 | ALPHA POLYGLUTAMATED PEMETREXED AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2024-05-30 | — | — | US | disclosed |
| US-20240024326-A1 | ALPHA POLYGLUTAMATED PRALATREXATE AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2024-01-25 | — | — | US | disclosed |
| US-11779584-B2 | Alpha polyglutamated pemetrexed and uses thereof | L.E.A.F. HOLDINGS GROUP LLC (US) | 2023-10-10 | — | — | US | disclosed |
| US-11771700-B2 | Gamma polyglutamated lometrexol and uses thereof | L.E.A.F. HOLDINGS GROUP LLC (US) | 2023-10-03 | — | — | US | disclosed |
| US-11730738-B2 | Alpha polyglutamated pralatrexate and uses thereof | L.E.A.F. HOLDINGS GROUP LLC (US) | 2023-08-22 | — | — | US | disclosed |
| US-20210346381-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2021-11-11 | — | — | US | disclosed |
| US-20210338675-A1 | ALPHA POLYGLUTAMATED LOMETREXOL AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2021-11-04 | — | — | US | disclosed |
| US-20210228581-A1 | GAMMA POLYGLUTAMATED LOMETREXOL AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2021-07-29 | — | — | US | disclosed |
| US-20210213019-A1 | GAMMA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2021-07-15 | — | — | US | disclosed |
| US-20210169887-A1 | ALPHA POLYGLUTAMATED METHOTREXATE AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2021-06-10 | — | — | US | disclosed |
| WO-2019157140-A1 | GAMMA POLYGLUTAMATED RALTITREXED AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019157120-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019157129-A1 | ALPHA POLYGLUTAMATED PRALATREXATE AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019157148-A1 | GAMMA POLYGLUTAMATED ANTIFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019157133-A1 | ALPHA POLYGLUTAMATED RALTITREXED AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019157145-A1 | GAMMA POLYGLUTAMATED PEMETREXED AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019157125-A1 | ALPHA POLYGLUTAMATED METHOTREXATE AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019157138-A1 | ALPHA POLYGLUTAMATED PEMETREXED AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019157121-A1 | ALPHA POLYGLUTAMATED LOMETREXOL AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019157123-A1 | ALPHA POLYGLUTAMATED AMINOPTERIN AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |