Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | KLK7 | P49862 | 2/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24392263 | 0.94 | NAMPT (0.51) | ABCB1MAPTHTTNAMPTKEAP1 | |
| SCHEMBL20659982 | 0.91 | KDM4E (0.56) | ABCB1HTTKEAP1NFE2L2ITGB3 | |
| SCHEMBL2826301 | 0.87 | NAMPT (0.61) | ABCB1MAPTHTTNAMPTLMNA | |
| SCHEMBL19063606 | 0.85 | KDM4E (0.53) | ABCB1HTTKEAP1NFE2L2ITGB3 | |
| SCHEMBL30990345 | 0.85 | KDM4E (0.53) | ABCB1HTTKEAP1NFE2L2ITGB3 | |
| SCHEMBL28765289 | 0.85 | ABCB1 (0.49) | ABCB1MAPTHTTKEAP1NFE2L2 | |
| SCHEMBL26939035 | 0.85 | ABCB1 (0.49) | ABCB1MAPTHTTKEAP1NFE2L2 | |
| SCHEMBL29130086 | 0.85 | ABCB1 (0.57) | ABCB1MAPTHTTKEAP1NFE2L2 | |
| SCHEMBL19063610 | 0.84 | ABCB1 (0.48) | ABCB1MAPTHTTNAMPTKEAP1 | |
| SCHEMBL19063614 | 0.84 | ABCB1 (0.48) | ABCB1MAPTHTTNAMPTKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3752498-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2019157458-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2019-08-15 | — | — | WO | disclosed |