Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.31 |
| ▸ | KHK | P50053 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | WNT1 | P04628 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17018279 | 0.89 | BRD4 (0.55) | BRD4GSK3BDYRK1AMETCREBBP | |
| SCHEMBL17018278 | 0.89 | BRD4 (0.55) | BRD4GSK3BDYRK1AMETCREBBP | |
| SCHEMBL17018282 | 0.88 | BRD4 (0.46) | BRD4GSK3BDYRK1ACREBBP | |
| SCHEMBL17018283 | 0.88 | BRD4 (0.46) | BRD4GSK3BDYRK1ACREBBP | |
| SCHEMBL17018281 | 0.86 | BRD4 (0.50) | BRD4GSK3BDYRK1AIDH1MET | |
| SCHEMBL17018280 | 0.86 | BRD4 (0.50) | BRD4GSK3BDYRK1AIDH1MET | |
| SCHEMBL21249959 | 0.83 | BRD4 (0.47) | BRD4GSK3BDYRK1ACREBBPTBK1 | |
| SCHEMBL23734020 | 0.81 | BRD4 (0.49) | BRD4GSK3BDYRK1AIDH1PIK3CD | |
| SCHEMBL17018102 | 0.79 | BRD4 (0.61) | BRD4CREBBPPIK3CDPIK3CAPIK3CB | |
| SCHEMBL17018120 | 0.79 | BRD4 (0.51) | BRD4GSK3BDYRK1ACREBBPPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377769-B2 | Benzopiperazine compositions as BET bromodomain inhibitors | FORMA THERAPEUTICS, INC. (US) | 2019-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10377769-B2 | Benzopiperazine compositions as BET bromodomain inhibitors | BRD4, BRPF3, BRD7 | BRD4 1/4885GSK3B 1719/4885DYRK1A 2181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.