Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 14/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252103 | 0.82 | FGFR1 (0.58) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL20330738 | 0.82 | FGFR4 (0.79) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL29579179 | 0.82 | FGFR4 (0.79) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21252041 | 0.81 | FGFR4 (0.51) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21252089 | 0.80 | FGFR1 (0.54) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21252159 | 0.79 | FGFR4 (0.51) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21251998 | 0.77 | FGFR4 (0.46) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21251981 | 0.75 | FGFR4 (0.53) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL21252113 | 0.73 | FGFR1 (0.47) | FGFR4FGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL24488261 | 0.73 | ALK (0.47) | FGFR4FGFR1FGFR2FGFR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |