Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 15/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 13/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | YES1 | P07947 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21251976 | 0.91 | FGFR1 (0.50) | FGFR1FGFR4CHEK1FGFR2FGFR3 | |
| SCHEMBL21252339 | 0.90 | FGFR1 (0.50) | FGFR1FGFR4FGFR2FGFR3PDGFRA | |
| SCHEMBL20330528 | 0.88 | FGFR1 (0.66) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL30046401 | 0.88 | FGFR1 (0.66) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL30045297 | 0.79 | FGFR4 (0.66) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL20330526 | 0.79 | FGFR4 (0.66) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL20330520 | 0.78 | FGFR1 (0.65) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL30044812 | 0.78 | FGFR1 (0.65) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL15618653 | 0.72 | CCNA2 (0.43) | FGFR1FGFR4CHEK1FGFR2SYK | |
| SCHEMBL21252246 | 0.72 | FGFR3 (0.46) | FGFR1FGFR4CHEK1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |