Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 20/20 | 0.74 |
| ▸ | BRD4 | O60885 | 16/20 | 0.74 |
| ▸ | EP300 | Q09472 | 3/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17785747 | 0.87 | CREBBP (0.79) | CREBBPBRD4EP300 | |
| SCHEMBL17794716 | 0.85 | CREBBP (1.00) | CREBBPBRD4EP300 | |
| SCHEMBL17795550 | 0.82 | CREBBP (1.00) | CREBBPBRD4EP300 | |
| SCHEMBL17795029 | 0.81 | CREBBP (0.82) | CREBBPBRD4 | |
| SCHEMBL17785630 | 0.80 | CREBBP (0.76) | CREBBPBRD4EP300 | |
| SCHEMBL17794983 | 0.80 | CREBBP (1.00) | CREBBPBRD4EP300 | |
| SCHEMBL17795223 | 0.79 | CREBBP (1.00) | CREBBPBRD4EP300 | |
| SCHEMBL17806749 | 0.78 | CREBBP (0.73) | CREBBPBRD4EP300 | |
| SCHEMBL17795058 | 0.78 | CREBBP (1.00) | CREBBPBRD4EP300 | |
| SCHEMBL17795219 | 0.78 | CREBBP (1.00) | CREBBPBRD4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3224258-B1 | 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH INC (US) | 2019-08-14 | — | — | EP | disclosed |