Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.55 |
| ▸ | KDM5C | P41229 | 1/20 | 0.55 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.48 |
| ▸ | KDM5A | P29375 | 5/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21257752 | 0.99 | KDM4C (0.54) | KDM4CKDM5CKDM2BKDM5AKDM5B | |
| SCHEMBL21257581 | 0.92 | KDM4C (0.47) | KDM4CKDM5CKDM2BKDM5AKDM5B | |
| SCHEMBL21257809 | 0.89 | KDM4C (0.51) | KDM4CKDM5CKDM2BKDM5AKDM5B | |
| SCHEMBL21257720 | 0.88 | KDM4C (0.50) | KDM4CKDM5CKDM2BKDM5AKDM5B | |
| SCHEMBL21257664 | 0.87 | KDM4C (0.48) | KDM4CKDM5CKDM2BKDM5AKDM5B | |
| SCHEMBL21257697 | 0.85 | PIK3CA (0.46) | KDM4CKDM5CKDM5AKDM5BPOLB | |
| SCHEMBL15636461 | 0.83 | KDM4C (0.76) | KDM4CKDM5CKDM2BKDM5AKDM5B | |
| SCHEMBL2305288 | 0.80 | KDM4C (0.76) | KDM4CKDM5CKDM2BKDM5AKDM5B | |
| SCHEMBL21257580 | 0.79 | PIK3CA (0.41) | KDM4CKDM5CKDM5AKDM5BPOLB | |
| SCHEMBL16291774 | 0.79 | KDM4C (0.74) | KDM4CKDM5CKDM2BKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019154261-A1 | PYRIDINE DERIVATIVE RELATED TO KMD5 PATHWAY | 南京明德新药研发股份有限公司 | 2019-08-15 | — | — | WO | disclosed |