Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.39 |
| ▸ | BRD7 | Q9NPI1 | 3/20 | 0.39 |
| ▸ | TAF1 | P21675 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | CECR2 | Q9BXF3 | 2/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.39 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | ATAD2B | Q9ULI0 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 14/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.36 |
| ▸ | BRD8 | Q9H0E9 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21259434 | 0.76 | BRD9 (0.38) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL22306886 | 0.64 | BRD4 (0.46) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL22872873 | 0.64 | BRD4 (0.44) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL23134035 | 0.63 | BRD9 (0.64) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL28783603 | 0.62 | BRD9 (0.49) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL16651223 | 0.62 | BRD4 (0.46) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL23783324 | 0.62 | HASPIN (0.49) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL21227711 | 0.62 | BRD4 (0.77) | BRD4 | |
| SCHEMBL23134703 | 0.60 | BRD4 (0.54) | BRD9BRD7TAF1TGFBR1ACVR1 | |
| SCHEMBL28783578 | 0.60 | BRD9 (0.48) | BRD9BRD7TAF1TGFBR1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190247509-A1 | DEGRADATION OF BROMODOMAIN-CONTAINING PROTEIN 9 (BRD9) BY CONJUGATION OF BRD9 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. | 2019-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190247509-A1 | DEGRADATION OF BROMODOMAIN-CONTAINING PROTEIN 9 (BRD9) BY CONJUGATION OF BRD9 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BRD9, BRWD1, BRD1 | BRD9 1/4885BRD7 6/4885TAF1 816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.