Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21246662 | 0.85 | POLB (0.33) | POLBHTTSMN1; SMN2 | |
| SCHEMBL22556134 | 0.84 | POLB (0.40) | POLBHTTSMN1; SMN2 | |
| SCHEMBL21262186 | 0.77 | POLB (0.40) | POLBHTTSMN1; SMN2HPGDMEN1 | |
| SCHEMBL22578870 | 0.74 | SMN1; SMN2 (0.35) | POLBHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL22578857 | 0.74 | POLB (0.39) | POLBHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL26310716 | 0.74 | POLB (0.36) | POLBHTTSMN1; SMN2LMNACYP3A4 | |
| SCHEMBL22578993 | 0.72 | SMN1; SMN2 (0.34) | POLBHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL22578995 | 0.72 | MAPT (0.34) | POLBHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL26310926 | 0.70 | SMN1; SMN2 (0.33) | POLBHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5680039 | 0.69 | TARBP2 (0.49) | POLBHTTTARBP2LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019153080-A1 | INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2019-08-15 | — | — | WO | disclosed |