Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 8/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21263561 | 0.95 | TOP1 (0.44) | TOP1HDAC3HDAC1HDAC6KDM4E | |
| SCHEMBL21263577 | 0.94 | TOP1 (0.44) | TOP1HDAC3HDAC1HDAC6KDM4E | |
| SCHEMBL21138196 | 0.92 | TOP1 (0.43) | TOP1HDAC3HDAC1HDAC6KDM4E | |
| SCHEMBL21263564 | 0.90 | TOP1 (0.43) | TOP1HDAC3HDAC1HDAC6KDM4E | |
| SCHEMBL21263575 | 0.90 | TOP1 (0.43) | TOP1HDAC3HDAC1HDAC6KDM4E | |
| SCHEMBL22618819 | 0.90 | TOP1 (0.44) | TOP1HDAC3HDAC1HDAC6KDM4E | |
| SCHEMBL21263601 | 0.90 | TOP1 (0.44) | TOP1HDAC3HDAC1HDAC6KDM4E | |
| SCHEMBL21263578 | 0.89 | TOP1 (0.45) | TOP1HDAC3HDAC1HDAC6KDM4E | |
| SCHEMBL21137833 | 0.86 | ELANE (0.42) | TOP1HDAC3HDAC1HDAC6KDM4E | |
| SCHEMBL22618774 | 0.86 | TOP1 (0.44) | TOP1HDAC3HDAC1HDAC6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019154120-A1 | CYTOTOXIC AGENT AND CONJUGATE THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2019-08-15 | — | — | WO | disclosed |