Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.63 |
| ▸ | P2RY14 | Q15391 | 18/20 | 0.60 |
| ▸ | DRD5 | P21918 | 4/20 | 0.58 |
| ▸ | DRD1 | P21728 | 3/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.58 |
| ▸ | HTR1D | P28221 | 2/20 | 0.58 |
| ▸ | HTR5A | P47898 | 2/20 | 0.58 |
| ▸ | HTR1E | P28566 | 1/20 | 0.58 |
| ▸ | TSPO | P30536 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3751405 | 0.86 | TMEM97 (0.73) | TMEM97P2RY14DRD5DRD1DRD3 | |
| SCHEMBL2934966 | 0.84 | P2RY14 (0.81) | TMEM97P2RY14DRD5DRD1DRD3 | |
| SCHEMBL30195542 | 0.84 | P2RY14 (0.81) | TMEM97P2RY14DRD5DRD1DRD3 | |
| SCHEMBL22996142 | 0.84 | TMEM97 (0.65) | TMEM97P2RY14DRD5DRD1DRD3 | |
| SCHEMBL21247893 | 0.84 | P2RY14 (0.77) | TMEM97P2RY14DRD5DRD1DRD3 | |
| SCHEMBL21247964 | 0.82 | P2RY14 (0.81) | TMEM97P2RY14DRD5DRD1DRD3 | |
| SCHEMBL2935177 | 0.81 | P2RY14 (0.75) | TMEM97P2RY14DRD5DRD1DRD3 | |
| SCHEMBL21248482 | 0.81 | P2RY14 (0.84) | TMEM97P2RY14DRD5DRD1DRD3 | |
| SCHEMBL2932405 | 0.80 | TMEM97 (0.65) | TMEM97P2RY14DRD5DRD1DRD3 | |
| SCHEMBL21248047 | 0.80 | P2RY14 (0.79) | TMEM97P2RY14DRD5DRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019157417-A1 | HETEROCYCLIC P2Y14 RECEPTOR ANTAGONISTS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-08-15 | — | — | WO | disclosed |