⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10947641 | 0.87 | — | — | |
| SCHEMBL10943263 | 0.84 | — | — | |
| SCHEMBL19597429 | 0.82 | — | — | |
| SCHEMBL14524398 | 0.82 | — | — | |
| SCHEMBL10948165 | 0.78 | — | — | |
| SCHEMBL10945804 | 0.78 | — | — | |
| SCHEMBL10943798 | 0.78 | — | — | |
| SCHEMBL10947162 | 0.78 | — | — | |
| SCHEMBL575853 | 0.75 | — | — | |
| SCHEMBL575889 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160376591-A1 | iRNA AGENTS WITH BIOCLEAVABLE TETHERS | BANK OF AMERICA, N.A. | 2016-12-29 | — | — | US | disclosed |
| US-9476045-B2 | iRNA agents with biocleavable tethers | ALNYLAM PHARMACEUTICALS, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-20150073133-A1 | iRNA AGENTS WITH BIOCLEAVABLE TETHERS | BANK OF AMERICA, N.A. | 2015-03-12 | — | — | US | disclosed |
| US-8865677-B2 | iRNA agents with biocleavable tethers | ALNYLAM PHARMACEUTICALS, INC. (US) | 2014-10-21 | — | — | US | disclosed |
| EP-2444532-B1 | IODINE- AND AMYLOSE-CONTAINING FIBERS, METHOD FOR PRODUCTION THEREOF, AND USE THEREOF | OMIKENSHI KK (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-20130281685-A1 | iRNA AGENTS WITH BIOCLEAVABLE TETHERS | BANK OF AMERICA, N.A. | 2013-10-24 | — | — | US | disclosed |
| US-8426377-B2 | iRNA agents with biocleavable tethers | ALNYLAM PHARMACEUTICALS, INC. (US) | 2013-04-23 | — | — | US | disclosed |
| EP-2444532-A1 | IODINE- AND AMYLASE-CONTAINING FIBERS, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF | Omikenshi Co., Ltd. (JP) | 2012-04-25 | — | — | EP | disclosed |
| US-20100267941-A1 | IRNA AGENTS WITH BIOCLEAVABLE TETHERS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2010-10-21 | — | — | US | disclosed |