Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 10/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL598048 | 0.80 | PARP1 (0.46) | PARP1MTNR1ASLC22A12CYP2C19ENPP1 | |
| SCHEMBL8134942 | 0.77 | PARP1 (0.44) | PARP1MTNR1ASLC22A12CYP2C19ENPP1 | |
| SCHEMBL8135638 | 0.77 | PARP1 (0.47) | PARP1MTNR1ASLC22A12CYP2C19SLC22A6 | |
| SCHEMBL20181945 | 0.74 | PARP1 (0.41) | PARP1MTNR1ASLC22A12CYP2C19L3MBTL1 | |
| SCHEMBL31129863 | 0.74 | USP5 (0.47) | USP5ALDH1A1 | |
| SCHEMBL526316 | 0.73 | NOTUM (0.49) | CYP2C19L3MBTL1 | |
| SCHEMBL23938013 | 0.73 | PARP1 (0.46) | PARP1MTNR1ASLC22A12CYP2C19ENPP1 | |
| SCHEMBL30991276 | 0.73 | PARP1 (0.46) | PARP1MTNR1ASLC22A12CYP2C19ENPP1 | |
| SCHEMBL27518654 | 0.73 | PARP1 (0.41) | PARP1MTNR1ASLC22A12CYP2C19ENPP1 | |
| SCHEMBL1093566 | 0.73 | PARP1 (0.42) | PARP1MTNR1ASLC22A12CYP2C19ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443115-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010145201-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |