Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 8/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 12/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571520 | 0.84 | CHRM1 (0.46) | CHRM1CHRM2CHRM4CHRM3HCRTR1 | |
| SCHEMBL984050 | 0.83 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL981707 | 0.79 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL2126030 | 0.78 | CHRM1 (0.43) | CHRM1CHRM2CHRM4CHRM3HCRTR1 | |
| SCHEMBL983914 | 0.76 | HCRTR1 (0.43) | CHRM1CHRM2CHRM3HCRTR1HCRTR2 | |
| SCHEMBL2126618 | 0.75 | HCRTR1 (0.47) | CHRM1CHRM2CHRM4CHRM3HCRTR1 | |
| SCHEMBL2126112 | 0.75 | HCRTR1 (0.62) | HCRTR1HCRTR2 | |
| SCHEMBL986632 | 0.74 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL1339152 | 0.74 | HCRTR1 (0.58) | HCRTR1HCRTR2 | |
| SCHEMBL11896882 | 0.73 | HCRTR1 (0.45) | CHRM1CHRM2CHRM4CHRM3HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247586-B1 | 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-04-25 | — | — | EP | disclosed |