Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10007067 | 0.80 | MEN1 (0.37) | MAPK1TP53SMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL10303752 | 0.80 | MEN1 (0.37) | MAPK1TP53SMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL10008528 | 0.80 | MEN1 (0.37) | MAPK1TP53SMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL15722432 | 0.80 | MEN1 (0.37) | MAPK1TP53SMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL2130851 | 0.80 | MEN1 (0.37) | MAPK1TP53SMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL3420968 | 0.76 | CYP2C19 (0.33) | MAPK1TP53NFKB1CYP2C19THPO | |
| SCHEMBL27447748 | 0.75 | CYP2C19 (0.36) | CYP2C19SMN1; SMN2 | |
| SCHEMBL10303950 | 0.71 | — | — | |
| SCHEMBL7427322 | 0.71 | F10 (0.43) | MAPK1TP53NFKB1CYP2C19THPO | |
| SCHEMBL15619079 | 0.71 | F10 (0.43) | MAPK1TP53NFKB1CYP2C19THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2442809-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Incorporated (US) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010148197-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-23 | — | — | WO | disclosed |