Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11766616 | 0.80 | MAPT (0.47) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL637259 | 0.77 | KDM4E (0.38) | LMNANPC1RAB9AKMT2AMAPT | |
| SCHEMBL637260 | 0.77 | KDM4E (0.38) | LMNANPC1RAB9AKMT2AMAPT | |
| SCHEMBL12305566 | 0.75 | NPC1 (0.46) | LMNANPC1RAB9AKMT2AMAPT | |
| SCHEMBL18395052 | 0.72 | KDM4E (0.31) | MAPTKDM4EGAAPOLBALDH1A1 | |
| SCHEMBL18395050 | 0.72 | KDM4E (0.31) | MAPTKDM4EGAAPOLBALDH1A1 | |
| SCHEMBL7649176 | 0.72 | NPC1 (0.43) | LMNANPC1RAB9AKMT2AMAPT | |
| SCHEMBL12056323 | 0.72 | MAPT (0.40) | LMNANPC1RAB9AKMT2AMAPT | |
| SCHEMBL11762909 | 0.71 | MEN1 (0.45) | LMNANPC1RAB9AKMT2AMAPT | |
| SCHEMBL18856619 | 0.71 | NPC1 (0.42) | LMNANPC1RAB9AKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083630-B1 | PROCESS METHODS FOR PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2019-08-21 | — | — | EP | disclosed |