Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 11/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22828524 | 0.91 | FGFR3 (0.44) | FGFR3FGFR4FGFR1FGFR2CYP3A4 | |
| SCHEMBL15244132 | 0.84 | FGFR3 (0.50) | FGFR3FGFR4FGFR1FGFR2CYP3A4 | |
| SCHEMBL22807283 | 0.84 | FGFR3 (0.45) | FGFR3FGFR4FGFR1FGFR2CYP3A4 | |
| SCHEMBL21386636 | 0.82 | FGFR3 (0.57) | FGFR3FGFR4FGFR1FGFR2CYP3A4 | |
| SCHEMBL15244316 | 0.78 | FGFR3 (0.50) | FGFR3FGFR4FGFR1FGFR2CYP3A4 | |
| SCHEMBL29489954 | 0.78 | FGFR3 (0.45) | FGFR3FGFR4FGFR1FGFR2CYP3A4 | |
| SCHEMBL22807284 | 0.78 | FGFR3 (0.45) | FGFR3FGFR4FGFR1FGFR2CYP3A4 | |
| SCHEMBL18131765 | 0.78 | FGFR1 (0.45) | FGFR3FGFR4FGFR1FGFR2CYP3A4 | |
| SCHEMBL15244002 | 0.78 | FGFR4 (0.45) | FGFR3FGFR4FGFR1FGFR2CYP3A4 | |
| SCHEMBL15725732 | 0.77 | FGFR3 (0.44) | FGFR3FGFR4FGFR1FGFR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220362245-A1 | COMPOUNDS FOR INHIBITING FGFR4 | TERNS PHARMACEUTICALS, INC. (US) | 2022-11-17 | — | — | US | disclosed |
| EP-3986405-A1 | COMPOUNDS FOR INHIBITING FGFR4 | Terns Pharmaceuticals, Inc. (US) | 2022-04-27 | — | — | EP | disclosed |
| CN-114144176-A | Compounds for inhibiting FGFR4 | 拓臻制药公司 | 2022-03-04 | — | — | CN | disclosed |
| US-11008292-B2 | FGFR4 inhibitor and preparation method and use thereof | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2021-05-18 | — | — | US | disclosed |
| EP-3543227-B1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2020-12-30 | — | — | EP | disclosed |
| WO-2020257527-A1 | COMPOUNDS FOR INHIBITING FGFR4 | Terns, Inc. (US) | 2020-12-24 | — | — | WO | disclosed |
| US-20200062716-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2020-02-27 | — | — | US | disclosed |
| EP-3543227-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | Guangdong Zhongsheng Pharmaceutical Co., Ltd (CN) | 2019-09-25 | — | — | EP | disclosed |
| EP-2821402-B1 | NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC (JP) | 2019-08-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11008292-B2 | FGFR4 inhibitor and preparation method and use thereof | FGFR4, FGFR1, FGFR2 | FGFR3 4/4885FGFR4 1/4885FGFR1 2/4885 |
| US-20220362245-A1 | COMPOUNDS FOR INHIBITING FGFR4 | FGFR4, FGFR1, FGFR3 | FGFR3 3/4885FGFR4 1/4885FGFR1 2/4885 |
| US-20200062716-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | FGFR4, FGFR1, FGFR2 | FGFR3 4/4885FGFR4 1/4885FGFR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.