Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 2/20 | 0.49 |
| ▸ | PNP | P00491 | 9/20 | 0.46 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10508430 | 0.89 | HPRT1 (0.48) | HPRT1PNPTYMSXDH | |
| SCHEMBL10506834 | 0.89 | HPRT1 (0.45) | HPRT1PNPTYMSXDH | |
| SCHEMBL10509001 | 0.88 | HPRT1 (0.47) | HPRT1PNPTYMSNOS1 | |
| SCHEMBL10509301 | 0.88 | HPRT1 (0.50) | HPRT1PNPTYMSXDH | |
| SCHEMBL9798211 | 0.87 | HPRT1 (0.45) | HPRT1PNP | |
| SCHEMBL9503635 | 0.86 | PNP (0.47) | HPRT1PNPTYMSNOS1QTRT1 | |
| SCHEMBL10507662 | 0.85 | HPRT1 (0.50) | HPRT1PNPTYMSQTRT1XDH | |
| SCHEMBL10508309 | 0.85 | TYMS (0.49) | HPRT1PNPTYMSXDH | |
| SCHEMBL10507190 | 0.84 | HPRT1 (0.47) | HPRT1PNPTYMSXDH | |
| SCHEMBL9798158 | 0.81 | PNP (0.50) | HPRT1PNPNOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012145794-A1 | METHOD OF DETERMINING RESPONSE TO TREATMENT WITH IMMUNOMODULATORY COMPOSITION | THE UNIVERSITY OF SYDNEY (AU) | 2012-11-01 | — | — | WO | claimed |
| EP-2443257-A1 | METHOD OF DETERMINING RESPONSE TO TREATMENT WITH IMMUNOMODULATORY COMPOSITION | The University Of Sydney (AU) | 2012-04-25 | — | — | EP | claimed |
| WO-2011146985-A1 | METHOD OF DETERMINING RESPONSE TO TREATMENT WITH IMMUNOMODULATORY COMPOSITION | THE UNIVERSITY OF SYDNEY (AU) | 2011-12-01 | — | — | WO | claimed |
| WO-2010144946-A1 | METHOD OF DETERMINING RESPONSE TO TREATMENT WITH IMMUNOMODULATORY COMPOSITION | THE UNIVERSITY OF SYDNEY (AU) | 2010-12-23 | — | — | WO | claimed |
| US-20100316608-A1 | Method of Determining A Response To Treatment With Immunomodulatory Composition | WESTERN SYDNEY LOCAL HEALTH DISTRICT (AU) | 2010-12-16 | — | — | US | claimed |
| WO-2012145794-A1 | METHOD OF DETERMINING RESPONSE TO TREATMENT WITH IMMUNOMODULATORY COMPOSITION | THE UNIVERSITY OF SYDNEY (AU) | 2012-11-01 | — | — | WO | disclosed |
| US-20120183497-A1 | Method of Determining Response to Treatment with Immunomodulatory Composition | GEORGE JACOB (AU) | 2012-07-19 | — | — | US | disclosed |
| EP-2443257-A1 | METHOD OF DETERMINING RESPONSE TO TREATMENT WITH IMMUNOMODULATORY COMPOSITION | The University Of Sydney (AU) | 2012-04-25 | — | — | EP | disclosed |
| WO-2011146985-A1 | METHOD OF DETERMINING RESPONSE TO TREATMENT WITH IMMUNOMODULATORY COMPOSITION | THE UNIVERSITY OF SYDNEY (AU) | 2011-12-01 | — | — | WO | disclosed |
| WO-2010144946-A1 | METHOD OF DETERMINING RESPONSE TO TREATMENT WITH IMMUNOMODULATORY COMPOSITION | THE UNIVERSITY OF SYDNEY (AU) | 2010-12-23 | — | — | WO | disclosed |
| US-20100316608-A1 | Method of Determining A Response To Treatment With Immunomodulatory Composition | WESTERN SYDNEY LOCAL HEALTH DISTRICT (AU) | 2010-12-16 | — | — | US | disclosed |
| US-4874862-A | Process for preparing guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1989-10-17 | — | — | US | disclosed |
| EP-0156559-B1 | 8-SUBSTITUTED GUANINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1989-08-02 | — | — | EP | disclosed |
| US-4748177-A | Guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0156559-A2 | 8-Substituted guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1985-10-02 | — | — | EP | disclosed |