Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 18/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 18/20 | 0.78 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.78 |
| ▸ | HDAC7 | Q8WUI4 | 18/20 | 0.78 |
| ▸ | HDAC2 | Q92769 | 18/20 | 0.78 |
| ▸ | HDAC10 | Q969S8 | 18/20 | 0.78 |
| ▸ | HDAC11 | Q96DB2 | 18/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 18/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.78 |
| ▸ | HDAC9 | Q9UKV0 | 18/20 | 0.78 |
| ▸ | HDAC5 | Q9UQL6 | 18/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.42 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2128446 | 1.00 | HDAC3 (0.78) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2130415 | 0.89 | HDAC3 (0.82) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2130408 | 0.89 | HDAC3 (0.82) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2127028 | 0.88 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2127023 | 0.88 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2129028 | 0.87 | HDAC3 (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2129022 | 0.87 | HDAC3 (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1175982 | 0.86 | HDAC3 (0.78) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1175979 | 0.86 | HDAC3 (0.78) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2126705 | 0.84 | HDAC3 (0.78) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592444-B2 | Spirocyclic derivatives as histone deacetylase inhibitors | DAC S.R.L. (IT) | 2013-11-26 | — | — | US | disclosed |
| EP-2279187-B9 | Spirocyclic derivatives as histone deacetylase inhibitors | DAC SRL (IT) | 2012-12-12 | — | — | EP | disclosed |
| EP-2279187-B1 | Spirocyclic derivatives as histone deacetylase inhibitors | DAC SRL (IT) | 2012-04-25 | — | — | EP | disclosed |
| EP-2110377-A1 | Spirocyclic derivatives as histone deacetylase inhibitors | DAC S.r.l. (IT) | 2009-10-21 | — | — | EP | disclosed |