Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 16/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21287485 | 1.00 | PTPN11 (0.44) | PTPN11 | |
| SCHEMBL22049983 | 1.00 | PTPN11 (0.44) | PTPN11 | |
| SCHEMBL24097901 | 1.00 | PTPN11 (0.44) | PTPN11 | |
| SCHEMBL21287487 | 1.00 | PTPN11 (0.44) | PTPN11 | |
| SCHEMBL24091155 | 0.80 | PTPN11 (0.41) | PTPN11 | |
| SCHEMBL23022406 | 0.80 | PTPN11 (0.42) | PTPN11 | |
| SCHEMBL23022404 | 0.80 | PTPN11 (0.41) | PTPN11 | |
| SCHEMBL20909177 | 0.80 | PTPN11 (0.42) | PTPN11 | |
| SCHEMBL21845141 | 0.80 | PTPN11 (0.39) | PTPN11 | |
| SCHEMBL20909428 | 0.80 | PTPN11 (0.39) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4328228-A1 | HETEROCYCLIC COMPOUND FOR INHIBITING SHP2 ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2024-02-28 | — | — | EP | disclosed |
| EP-3753941-A1 | PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shanghai Blueray Biopharma Co., Ltd. (CN) | 2020-12-23 | — | — | EP | disclosed |
| WO-2020210384-A1 | PYRIMIDINONE DERIVATIVES AS SHP2 ANTAGONISTS | MERCK PATENT GMBH (DE) | 2020-10-15 | — | — | WO | disclosed |
| WO-2019158019-A1 | PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海青煜医药科技有限公司 | 2019-08-22 | — | — | WO | disclosed |