Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.66 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12450359 | 0.85 | SPHK1 (0.63) | SPHK1SPHK2CYP3A4KMT2AMEN1 | |
| SCHEMBL20651369 | 0.85 | SPHK1 (0.63) | SPHK1SPHK2CYP3A4KMT2AMEN1 | |
| SCHEMBL17072198 | 0.83 | SPHK1 (0.48) | SPHK1SPHK2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL17072197 | 0.83 | SPHK1 (0.48) | SPHK1SPHK2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL17072196 | 0.83 | SPHK1 (0.48) | SPHK1SPHK2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL20905106 | 0.79 | SPHK1 (0.70) | SPHK1SPHK2CYP2C19CYP2C9PTGS1 | |
| SCHEMBL18194573 | 0.79 | SPHK1 (1.00) | SPHK1SPHK2CYP3A4CYP2C9PTGS1 | |
| SCHEMBL20596127 | 0.79 | SPHK1 (1.00) | SPHK1SPHK2CYP3A4CYP2C9PTGS1 | |
| SCHEMBL20592376 | 0.79 | SPHK1 (1.00) | SPHK1SPHK2CYP3A4CYP2C9PTGS1 | |
| SCHEMBL120911 | 0.79 | SPHK1 (1.00) | SPHK1SPHK2CYP3A4CYP2C9PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10683257-B2 | Methods and intermediates for synthesizing SK1-I | ENZO BIOCHEM, INC. (US) | 2020-06-16 | — | — | US | disclosed |
| US-20200131113-A1 | METHODS AND INTERMEDIATES FOR SYNTHESIZING SK1-I | ENZO BIOCHEM, INC. (US) | 2020-04-30 | — | — | US | disclosed |
| US-20190256453-A1 | METHODS AND INTERMEDIATES FOR SYNTHESIZING SK1-I | ENZO BIOCHEM, INC. (US) | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10683257-B2 | Methods and intermediates for synthesizing SK1-I | SKP1, SKP2, KMT5A | SPHK1 23/4885SPHK2 59/4885CYP3A4 646/4885 |
| US-20200131113-A1 | METHODS AND INTERMEDIATES FOR SYNTHESIZING SK1-I | SKP1, SKP2, KMT5A | SPHK1 23/4885SPHK2 59/4885CYP3A4 646/4885 |
| US-20190256453-A1 | METHODS AND INTERMEDIATES FOR SYNTHESIZING SK1-I | SKP1, SKP2, KMT5A | SPHK1 23/4885SPHK2 59/4885CYP3A4 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.