SCHEMBL21296028

SCHEMBL21296028

CCCCCOc1ccc2c(c1)CCC(CN1CC(C(=O)O)C1)=C2C

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 20/20 0.79
S1PR3 Q99500 12/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL29446115 0.98 S1PR1 (0.76) S1PR1S1PR3
Hydrochloric Acid SCHEMBL947478 0.98 S1PR1 (0.76) S1PR1S1PR3
SCHEMBL22829433 0.98 S1PR1 (0.80) S1PR1S1PR3
Ammonia Solution, Strong SCHEMBL30815905 0.97 S1PR1 (0.79) S1PR1S1PR3
SCHEMBL21296069 0.91 S1PR1 (0.67) S1PR1S1PR3
SCHEMBL949508 0.88 S1PR1 (1.00) S1PR1S1PR3
Biphenyl SCHEMBL27642578 0.88 S1PR1 (0.77) S1PR1S1PR3
SCHEMBL1871664 0.88 S1PR1 (0.86) S1PR1S1PR3
SCHEMBL21300600 0.88 S1PR1 (0.65) S1PR1S1PR3
SCHEMBL30816058 0.88 S1PR1 (0.65) S1PR1S1PR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240327342-A1 COMPOUNDS HAVING S1P5 RECEPTOR AGONISTIC ACTIVITY ONO PHARMACEUTICAL CO., LTD. (JP) 2024-10-03 US disclosed
EP-4431157-A2 1-[[(3S)-3-METHYL-6-(4(4,4-TRIFLUOROBUTOXY)-3,4-DIHYDRONAPHTHALEN-2YL]METHYL]AZETIDINE-3-CARBOXYLIC ACID HAVING S1P5 RECEPTOR AGONIST ACTIVITY FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS AND CANCER ONO Pharmaceutical Co., Ltd. (JP) 2024-09-18 EP disclosed
US-12049445-B2 Compounds having S1P5 receptor agonistic activity ONO PHARMACEUTICAL CO., LTD. (JP) 2024-07-30 US disclosed
CN-111757869-B Compounds having S1P5 receptor agonistic activity 小野药品工业株式会社 2024-03-08 CN disclosed
US-20220055986-A1 COMPOUNDS HAVING S1P5 RECEPTOR AGONISTIC ACTIVITY ONO PHARMACEUTICAL CO., LTD. (JP) 2022-02-24 US disclosed
US-11198672-B2 Compounds having S1P5 receptor agonistic activity ONO PHARMACEUTICAL CO., LTD. (JP) 2021-12-14 US disclosed
US-11198672-B2 Compounds having S1P5 receptor agonistic activity ONO PHARMACEUTICAL CO., LTD. (JP) 2021-12-14 US disclosed
US-20210087141-A1 COMPOUNDS HAVING S1P5 RECEPTOR AGONISTIC ACTIVITY ONO PHARMACEUTICAL CO., LTD. (JP) 2021-03-25 US disclosed
US-20210087141-A1 COMPOUNDS HAVING S1P5 RECEPTOR AGONISTIC ACTIVITY ONO PHARMACEUTICAL CO., LTD. (JP) 2021-03-25 US disclosed
EP-3757091-A1 COMPOUND HAVING S1P5 RECEPTOR AGONIST ACTIVITY ONO Pharmaceutical Co., Ltd. (JP) 2020-12-30 EP disclosed
EP-3757091-A1 COMPOUND HAVING S1P5 RECEPTOR AGONIST ACTIVITY ONO Pharmaceutical Co., Ltd. (JP) 2020-12-30 EP disclosed
WO-2019163917-A1 COMPOUND HAVING S1P5 RECEPTOR AGONIST ACTIVITY 小野薬品工業株式会社 2019-08-29 WO disclosed
WO-2019163917-A1 COMPOUND HAVING S1P5 RECEPTOR AGONIST ACTIVITY 小野薬品工業株式会社 2019-08-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12049445-B2 Compounds having S1P5 receptor agonistic activity S1PR5, S1PR1, S1PR4 S1PR1 2/4885S1PR3 6/4885
US-20240327342-A1 COMPOUNDS HAVING S1P5 RECEPTOR AGONISTIC ACTIVITY S1PR5, S1PR1, S1PR4 S1PR1 2/4885S1PR3 6/4885
US-11198672-B2 Compounds having S1P5 receptor agonistic activity S1PR5, S1PR1, S1PR4 S1PR1 2/4885S1PR3 6/4885
US-20210087141-A1 COMPOUNDS HAVING S1P5 RECEPTOR AGONISTIC ACTIVITY S1PR5, S1PR1, S1PR4 S1PR1 2/4885S1PR3 6/4885
US-20220055986-A1 COMPOUNDS HAVING S1P5 RECEPTOR AGONISTIC ACTIVITY S1PR5, S1PR1, S1PR4 S1PR1 2/4885S1PR3 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.