SCHEMBL21301700

SCHEMBL21301700

Cc1c(C2CCC2)ccc(-c2cnc(N)cn2)c1F

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 19/20 0.74
ALOX5AP P20292 19/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21301896 0.95 FEN1 (0.66) FEN1ALOX5AP
SCHEMBL21301673 0.88 FEN1 (0.64) FEN1ALOX5AP
SCHEMBL15913263 0.85 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15912907 0.85 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL21301847 0.84 FEN1 (0.74) FEN1ALOX5AP
SCHEMBL15937261 0.84 FEN1 (0.74) FEN1ALOX5AP
SCHEMBL21301800 0.83 FEN1 (0.80) FEN1ALOX5AP
SCHEMBL15913284 0.82 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL21301570 0.82 FEN1 (0.67) FEN1ALOX5AP
SCHEMBL15930233 0.82 FEN1 (0.76) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2951169-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2019-08-28 EP disclosed