Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 19/20 | 0.75 |
| ▸ | GSK3B | P49841 | 15/20 | 0.75 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | CLK3 | P49761 | 2/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21292328 | 0.92 | DYRK1A (0.72) | DYRK1AGSK3BCLK2CLK3 | |
| SCHEMBL21292327 | 0.92 | DYRK1A (0.72) | DYRK1AGSK3BCLK2CLK3 | |
| SCHEMBL21292359 | 0.85 | DYRK1A (1.00) | DYRK1AGSK3BCLK2CLK3WNT1 | |
| SCHEMBL21292358 | 0.85 | DYRK1A (1.00) | DYRK1AGSK3BCLK2CLK3WNT1 | |
| SCHEMBL21312368 | 0.81 | GSK3B (0.72) | DYRK1AGSK3B | |
| SCHEMBL21292369 | 0.76 | DYRK1A (1.00) | DYRK1AGSK3BCLK2CLK3 | |
| SCHEMBL21292368 | 0.76 | DYRK1A (1.00) | DYRK1AGSK3BCLK2CLK3 | |
| SCHEMBL21312150 | 0.74 | DYRK1A (0.79) | DYRK1AGSK3BCLK2CLK3PRMT5 | |
| SCHEMBL21292345 | 0.74 | DYRK1A (1.00) | DYRK1AGSK3BCLK2CLK3WNT1 | |
| SCHEMBL21292366 | 0.72 | GSK3B (0.71) | DYRK1AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165192-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLE-3-CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED, LLC (US) | 2019-08-29 | — | — | WO | disclosed |