Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 10/20 | 0.81 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12964729 | 0.89 | AXL (1.00) | AXLFGFR1PDPK1 | |
| SCHEMBL12964793 | 0.88 | AXL (0.74) | AXLCDK2AURKACCNA2CCNA1 | |
| SCHEMBL12964797 | 0.87 | AXL (0.78) | AXLFGFR1KDR | |
| SCHEMBL12964795 | 0.85 | AXL (0.75) | AXLFGFR1ABL1BCRPDGFRA | |
| SCHEMBL12964796 | 0.84 | AXL (0.73) | AXL | |
| SCHEMBL25549973 | 0.83 | AXL (0.72) | AXLFGFR1 | |
| SCHEMBL25549942 | 0.82 | AXL (0.71) | AXLFGFR1CDK2AURKACCNA2 | |
| SCHEMBL12813489 | 0.82 | AXL (0.77) | AXLCDK1KDRJAK2 | |
| SCHEMBL12813376 | 0.82 | AXL (1.00) | AXLCDK1KDR | |
| SCHEMBL12964726 | 0.81 | AXL (0.70) | AXLCDK1KDRJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2693881-B1 | SUBSTITUTED N-PHENYLPYRIMIDIN-2-AMINE ANALOGS AS INHIBITORS OF THE AXL KINASE | UNIV UTAH RES FOUND (US) | 2019-09-04 | — | — | EP | disclosed |