Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.37 |
| ▸ | NEK2 | P51955 | 4/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21240179 | 0.89 | PDE10A (0.40) | FGFR4PDE10APDE3BPDE3AFGFR1 | |
| SCHEMBL21240344 | 0.87 | FGFR4 (0.39) | TTKFGFR4NEK2PDE10APDE3B | |
| SCHEMBL21240273 | 0.87 | PDE5A (0.39) | FGFR4NEK2FGFR1FGFR2 | |
| SCHEMBL21240563 | 0.86 | FGFR4 (0.35) | TTKFGFR4PDE10APDE3BPDE3A | |
| SCHEMBL20332256 | 0.85 | TTK (0.39) | TTKFGFR4PDE10AFGFR1 | |
| SCHEMBL21240510 | 0.85 | MAOB (0.38) | TTKFGFR4PDE10APDE3BPDE3A | |
| SCHEMBL20332255 | 0.85 | FGFR4 (0.37) | FGFR4PDE10AFGFR1FGFR2PDE1B | |
| SCHEMBL21240632 | 0.85 | SMN1; SMN2 (0.42) | FGFR4FGFR1FGFR2 | |
| SCHEMBL21240131 | 0.85 | SMN1; SMN2 (0.44) | FGFR4FGFR1FGFR2 | |
| SCHEMBL29579046 | 0.85 | SMN1; SMN2 (0.42) | FGFR4FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10968220-B2 | FGFR4 inhibitor, preparation method therefor and pharmaceutical use thereof | ABBISKO THERAPEUTICS CO., LTD. (CN) | 2021-04-06 | — | — | US | disclosed |
| US-20190270742-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO., LTD. (CN) | 2019-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190270742-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | FGFR4, FGFR2, FGFR1 | TTK 3818/4885FGFR4 1/4885NEK2 2860/4885 |
| US-10968220-B2 | FGFR4 inhibitor, preparation method therefor and pharmaceutical use thereof | FGFR4, FGFR2, FGFR1 | TTK 3818/4885FGFR4 1/4885NEK2 2860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.