Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 6/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.37 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 5/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16962419 | 1.00 | GPR183 (0.50) | GPR183APPENPP2ATXN2SMN1; SMN2 | |
| SCHEMBL16962421 | 1.00 | GPR183 (0.50) | GPR183APPENPP2ATXN2SMN1; SMN2 | |
| SCHEMBL21322927 | 0.90 | GPR183 (0.40) | GPR183ENPP2ATXN2 | |
| SCHEMBL16963519 | 0.90 | GPR183 (0.40) | GPR183ENPP2ATXN2 | |
| SCHEMBL16963518 | 0.90 | GPR183 (0.40) | GPR183ENPP2ATXN2 | |
| SCHEMBL21323348 | 0.89 | GPR183 (0.48) | GPR183ENPP2ATXN2 | |
| SCHEMBL21323347 | 0.89 | GPR183 (0.48) | GPR183ENPP2ATXN2 | |
| SCHEMBL16962640 | 0.89 | GPR183 (0.48) | GPR183ENPP2ATXN2 | |
| SCHEMBL16962642 | 0.89 | GPR183 (0.48) | GPR183ENPP2ATXN2 | |
| SCHEMBL16962919 | 0.89 | GPR183 (0.40) | GPR183ENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |