Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.35 |
| ▸ | BCL2L11 | O43521 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21333114 | 1.00 | KDM1A (0.44) | KDM1ASIGMAR1KDM4CBACE1SRD5A1 | |
| SCHEMBL22975956 | 0.85 | KDM1A (0.40) | KDM1ASIGMAR1KDM4CBACE1SRD5A1 | |
| SCHEMBL21344129 | 0.85 | KDM1A (0.40) | KDM1ASIGMAR1KDM4CBACE1SRD5A1 | |
| SCHEMBL22975958 | 0.85 | KDM1A (0.40) | KDM1ASIGMAR1KDM4CBACE1SRD5A1 | |
| SCHEMBL21333712 | 0.85 | KDM1A (0.47) | KDM1ASIGMAR1KDM4CBACE1SRD5A1 | |
| SCHEMBL21344593 | 0.73 | KDM1A (0.43) | KDM1ASIGMAR1KDM4CBACE1SRD5A1 | |
| SCHEMBL22975883 | 0.73 | KDM1A (0.43) | KDM1ASIGMAR1KDM4CBACE1SRD5A1 | |
| SCHEMBL23670718 | 0.72 | SRD5A1 (0.47) | KDM1ASIGMAR1KDM4CSRD5A1SRD5A2 | |
| SCHEMBL22975923 | 0.72 | KDM1A (0.38) | KDM1ASIGMAR1KDM4CBACE1SRD5A1 | |
| SCHEMBL22975922 | 0.72 | KDM1A (0.38) | KDM1ASIGMAR1KDM4CBACE1SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3762393-A1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | Amgen Inc. (US) | 2021-01-13 | — | — | EP | disclosed |
| WO-2019173181-A1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | AMGEN INC. (US) | 2019-09-12 | — | — | WO | disclosed |