Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | VEGFA | P15692 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 3/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 11/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | TET3 | O43151 | 1/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.35 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.35 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212545 | 0.92 | CNR1 (0.53) | CNR1GABRA5VEGFAFLT1EGLN1 | |
| SCHEMBL213232 | 0.90 | CNR1 (0.49) | CNR1GABRA5EGLN1CNR2CFTR | |
| SCHEMBL213032 | 0.89 | CNR1 (0.44) | CNR1CNR2CFTRCYP1A2HPGDS | |
| SCHEMBL212544 | 0.89 | CNR1 (0.40) | CNR1GABRA5VEGFAFLT1EGLN1 | |
| SCHEMBL211872 | 0.89 | CNR1 (0.40) | CNR1GABRA5VEGFAFLT1EGLN1 | |
| SCHEMBL14856856 | 0.88 | CNR1 (0.39) | CNR1GABRA5CNR2CYP3A4CYP2C9 | |
| SCHEMBL214841 | 0.87 | CNR1 (0.40) | CNR1GABRA5CNR2CFTRCYP3A4 | |
| SCHEMBL528736 | 0.86 | CNR1 (0.46) | CNR1CNR2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10031414 | 0.81 | CNR1 (0.61) | CNR1CNR2CFTR | |
| SCHEMBL212570 | 0.81 | CNR1 (0.61) | CNR1CNR2CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | claimed |
| EP-2271632-A1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. Hoffmann-La Roche AG (CH) | 2011-01-12 | — | — | EP | claimed |
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2271632-A1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. Hoffmann-La Roche AG (CH) | 2011-01-12 | — | — | EP | disclosed |