Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 3/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | OGA | O60502 | 1/20 | 0.46 |
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19012378 | 0.85 | OGA (0.51) | SMOHSD11B1HRH3OGASMN1; SMN2 | |
| SCHEMBL19001138 | 0.81 | OGA (0.47) | SMOHSD11B1HRH3OGASMN1; SMN2 | |
| SCHEMBL21336772 | 0.81 | OGA (0.47) | SMOHSD11B1HRH3OGASMN1; SMN2 | |
| SCHEMBL18436686 | 0.80 | OGA (0.46) | SMOHSD11B1HRH3OGASMN1; SMN2 | |
| SCHEMBL19012379 | 0.80 | OGA (0.46) | SMOHSD11B1HRH3OGASMN1; SMN2 | |
| SCHEMBL19012358 | 0.78 | SMO (0.47) | SMOHSD11B1HRH3OGASMN1; SMN2 | |
| SCHEMBL18436092 | 0.77 | OGA (0.54) | SMOHRH3OGASMN1; SMN2HPGD | |
| SCHEMBL19001112 | 0.77 | OGA (0.54) | SMOHSD11B1HRH3OGASMN1; SMN2 | |
| SCHEMBL17128345 | 0.76 | OGA (0.50) | SMOHRH3OGASMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL28341448 | 0.74 | OGA (0.49) | SMOHRH3OGASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |