Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16806429 | 0.92 | PIK3CD (0.36) | PIK3CDPIK3CGPIK3R1CSNK1EPIK3CB | |
| Hydrochloric Acid SCHEMBL16783802 | 0.92 | PIK3CD (0.36) | PIK3CDPIK3CGPIK3R1CSNK1EPIK3CB | |
| SCHEMBL16806427 | 0.86 | KDM5B (0.37) | PIK3CDPIK3CGPIK3R1CSNK1EPIK3CB | |
| SCHEMBL16783570 | 0.86 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| Hydrochloric Acid SCHEMBL16783821 | 0.85 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| Hydrochloric Acid SCHEMBL16783592 | 0.85 | KDM5B (0.36) | PIK3CDPIK3CGPIK3R1CSNK1EPIK3CB | |
| SCHEMBL16783531 | 0.85 | PIK3CD (0.53) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| Hydrochloric Acid SCHEMBL16783569 | 0.84 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL21337751 | 0.81 | PIK3CD (0.38) | PIK3CDPIK3CGPIK3R1CSNK1EPIK3CB | |
| SCHEMBL16783641 | 0.80 | PIK3CD (0.56) | PIK3CDPIK3CGPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083617-B1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-11 | — | — | EP | disclosed |