Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | HCK | P08631 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16783698 | 0.91 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16783541 | 0.83 | PIK3CD (0.54) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16783833 | 0.83 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16783759 | 0.83 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16783769 | 0.82 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| Hydrochloric Acid SCHEMBL16783803 | 0.82 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16783531 | 0.81 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16806470 | 0.81 | PIK3CD (0.64) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16783633 | 0.81 | PIK3CD (0.64) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16783570 | 0.81 | PIK3CD (0.52) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083617-B1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-11 | — | — | EP | disclosed |