Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 3/20 | 0.79 |
| ▸ | TRDMT1 | O14717 | 3/20 | 0.62 |
| ▸ | WDR5 | P61964 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | RBBP5 | Q15291 | 4/20 | 0.61 |
| ▸ | DPY30 | Q9C005 | 4/20 | 0.61 |
| ▸ | ASH2L | Q9UBL3 | 4/20 | 0.61 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.56 |
| ▸ | NNMT | P40261 | 3/20 | 0.55 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.54 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.54 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.54 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL469241 | 0.88 | EZH2 (1.00) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL18609673 | 0.88 | EZH2 (1.00) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL20612160 | 0.88 | EZH2 (1.00) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL15281887 | 0.88 | EZH2 (1.00) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL14706086 | 0.88 | EZH2 (1.00) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL17484640 | 0.88 | EZH2 (1.00) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL20612161 | 0.88 | EZH2 (0.74) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL21337956 | 0.88 | EZH2 (0.74) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL18612416 | 0.86 | EZH2 (0.79) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL805652 | 0.86 | EZH2 (0.91) | EZH2TRDMT1WDR5KMT2ARBBP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536314-A1 | INHIBITORS OF HUMAN EZH2, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2019-09-11 | — | — | EP | disclosed |