Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.59 |
| ▸ | ITK | Q08881 | 5/20 | 0.59 |
| ▸ | BTK | Q06187 | 10/20 | 0.54 |
| ▸ | JAK3 | P52333 | 4/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | TEC | P42680 | 1/20 | 0.54 |
| ▸ | TXK | P42681 | 1/20 | 0.54 |
| ▸ | BMX | P51813 | 1/20 | 0.54 |
| ▸ | CD69 | Q07108 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16697954 | 0.82 | EGFR (0.59) | EGFRITKBTKJAK3JAK2 | |
| SCHEMBL16697956 | 0.82 | EGFR (0.59) | EGFRITKBTKJAK3JAK2 | |
| SCHEMBL18463268 | 0.80 | EGFR (0.72) | EGFRITKBTKJAK3JAK2 | |
| SCHEMBL16391115 | 0.77 | EGFR (0.59) | EGFRITKBTKJAK3 | |
| SCHEMBL16391082 | 0.77 | EGFR (0.66) | EGFRITKBTKJAK3TEC | |
| SCHEMBL2351705 | 0.75 | EGFR (1.00) | EGFRITKBTK | |
| SCHEMBL16391063 | 0.75 | EGFR (0.67) | EGFRITKBTKJAK3 | |
| SCHEMBL16698236 | 0.75 | EGFR (0.67) | EGFRITKBTKJAK3 | |
| SCHEMBL16391058 | 0.75 | EGFR (0.67) | EGFRITKBTKJAK3 | |
| SCHEMBL12518586 | 0.75 | EGFR (1.00) | EGFRITKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019496-B1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | ACEA THERAPEUTICS INC (US) | 2019-09-11 | — | — | EP | disclosed |