Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.52 |
| ▸ | ITK | Q08881 | 7/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 8/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.49 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16697962 | 0.92 | EGFR (0.63) | EGFRITKBTKJAK3ERBB2 | |
| SCHEMBL16391064 | 0.92 | EGFR (0.63) | EGFRITKBTKJAK3ERBB2 | |
| SCHEMBL16391059 | 0.92 | EGFR (0.63) | EGFRITKBTKJAK3ERBB2 | |
| SCHEMBL16391058 | 0.82 | EGFR (0.67) | EGFRITKBTKJAK3ERBB2 | |
| SCHEMBL16698236 | 0.82 | EGFR (0.67) | EGFRITKBTKJAK3ERBB2 | |
| SCHEMBL16391063 | 0.82 | EGFR (0.67) | EGFRITKBTKJAK3ERBB2 | |
| SCHEMBL16391055 | 0.80 | EGFR (0.65) | EGFRITKBTKJAK3ERBB2 | |
| SCHEMBL16371328 | 0.80 | EGFR (0.65) | EGFRITKBTKJAK3ERBB2 | |
| SCHEMBL16371329 | 0.80 | EGFR (0.65) | EGFRITKBTKJAK3ERBB2 | |
| SCHEMBL16391083 | 0.77 | EGFR (0.78) | EGFRITKBTKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019496-B1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | ACEA THERAPEUTICS INC (US) | 2019-09-11 | — | — | EP | disclosed |