Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18591822 | 0.84 | SLC6A4 (0.42) | SLC6A2SLC6A4SLC6A3FFAR1GRIN1 | |
| SCHEMBL18591775 | 0.84 | SLC6A4 (0.42) | SLC6A2SLC6A4SLC6A3FFAR1GRIN1 | |
| SCHEMBL23350043 | 0.80 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3FFAR1KDM4E | |
| SCHEMBL22006216 | 0.80 | CHRM2 (0.36) | SLC6A2SLC6A4SLC6A3LNPEP | |
| SCHEMBL21899245 | 0.78 | ACACB (0.36) | ACACB | |
| SCHEMBL20329991 | 0.78 | TAAR1 (0.40) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18591830 | 0.77 | SLC6A4 (0.40) | SLC6A2SLC6A4SLC6A3CASR | |
| SCHEMBL18592220 | 0.77 | SLC6A4 (0.40) | SLC6A2SLC6A4SLC6A3CASR | |
| SCHEMBL18591762 | 0.77 | SLC6A4 (0.45) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24295133 | 0.77 | SLC6A4 (0.45) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11028088-B2 | Modulators of BTK proteolysis and methods of use | YALE UNIVERSITY (US) | 2021-06-08 | — | — | US | disclosed |
| US-20190276459-A1 | MODULATORS OF BTK PROTEOLYSIS AND METHODS OF USE | YALE UNIVERSITY | 2019-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11028088-B2 | Modulators of BTK proteolysis and methods of use | BTK, CBL, CRBN | ACACB 1780/4885TRIM24 1023/4885SLC6A2 4744/4885 |
| US-20190276459-A1 | MODULATORS OF BTK PROTEOLYSIS AND METHODS OF USE | BTK, CBL, CRBN | ACACB 1780/4885TRIM24 1023/4885SLC6A2 4744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.