Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.68 |
| ▸ | EED | O75530 | 13/20 | 0.63 |
| ▸ | RBBP4 | Q09028 | 13/20 | 0.63 |
| ▸ | SUZ12 | Q15022 | 13/20 | 0.63 |
| ▸ | AEBP2 | Q6ZN18 | 13/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25514351 | 0.93 | EZH2 (0.71) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21341798 | 0.92 | EZH2 (0.64) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21342087 | 0.89 | EZH2 (0.79) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21113425 | 0.86 | EZH2 (0.85) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21342101 | 0.86 | EZH2 (0.57) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21113119 | 0.86 | EZH2 (0.85) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19964678 | 0.86 | EZH2 (0.85) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19964929 | 0.85 | EZH2 (0.70) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL22872264 | 0.84 | EZH2 (0.66) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19964721 | 0.84 | EZH2 (0.61) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11661421-B2 | Indolizine compounds, preparation method and use thereof | HAIHE BIOPHARMA CO., LTD. (CN) | 2023-05-30 | — | — | US | disclosed |
| EP-3763712-B1 | INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | HAIHE BIOPHARMA CO LTD (CN) | 2021-11-24 | — | — | EP | disclosed |
| EP-3763712-A1 | INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | Shanghai Haihe Pharmaceutical Co., Ltd. (CN) | 2021-01-13 | — | — | EP | disclosed |
| US-20200399270-A1 | INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | HAIHE BIOPHARMA CO., LTD. (CN) | 2020-12-24 | — | — | US | disclosed |
| WO-2019170063-A1 | INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | 上海海和药物研究开发有限公司 | 2019-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11661421-B2 | Indolizine compounds, preparation method and use thereof | EZH1, EZH2, IKZF3 | EZH2 2/4885EED 12/4885RBBP4 1315/4885 |
| US-20200399270-A1 | INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | EZH1, EZH2, IKZF3 | EZH2 2/4885EED 12/4885RBBP4 1315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.