Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 19/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21345355 | 0.85 | ABL1 (0.61) | ABL1 | |
| SCHEMBL30437624 | 0.84 | ABL1 (0.69) | ABL1 | |
| SCHEMBL21345379 | 0.82 | ABL1 (0.75) | ABL1 | |
| SCHEMBL21333467 | 0.79 | ABL1 (0.69) | ABL1 | |
| SCHEMBL23296092 | 0.77 | CES1 (0.77) | ABL1 | |
| SCHEMBL31621242 | 0.77 | CES1 (0.77) | ABL1 | |
| SCHEMBL23191196 | 0.77 | ABL1 (0.66) | ABL1 | |
| SCHEMBL21333753 | 0.77 | ABL1 (0.66) | ABL1 | |
| SCHEMBL23191241 | 0.76 | ABL1 (0.69) | ABL1 | |
| SCHEMBL21346030 | 0.76 | ABL1 (1.00) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019173761-A1 | C-ABL TYROSINE KINASE INHIBITORY COMPOUND EMBODIMENTS AND METHODS OF MAKING AND USING THE SAME | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-09-12 | — | — | WO | disclosed |