Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19029192 | 0.93 | HDAC6 (0.59) | HDAC6HDAC3PIK3CGAPPHDAC8 | |
| Trifluoroacetic Acid SCHEMBL21352565 | 0.90 | PIK3CD (0.49) | HDAC6HDAC3PIK3CGAPPHDAC8 | |
| Trifluoroacetic Acid SCHEMBL21352546 | 0.86 | HDAC6 (0.50) | HDAC6HDAC3APPHDAC8HDAC1 | |
| SCHEMBL21352526 | 0.86 | APP (0.50) | HDAC6HDAC3PIK3CGAPPHDAC8 | |
| SCHEMBL2055188 | 0.86 | APP (0.58) | HDAC6HDAC3PIK3CGAPPPIK3CD | |
| SCHEMBL2055193 | 0.84 | KDM4E (0.60) | PIK3CGAPPPIK3CDPIP5K1CPIK3CA | |
| Trifluoroacetic Acid SCHEMBL21352534 | 0.83 | HDAC6 (0.55) | HDAC6HDAC3PIK3CGHDAC8HDAC1 | |
| Trifluoroacetic Acid SCHEMBL21352477 | 0.83 | HDAC6 (0.48) | HDAC6HDAC3HDAC8HDAC1HDAC2 | |
| SCHEMBL19029081 | 0.82 | PIK3CG (0.55) | HDAC6HDAC3PIK3CGAPPHDAC8 | |
| SCHEMBL2100098 | 0.80 | APP (0.54) | PIK3CGAPPPIK3CDPIP5K1CPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3394052-B1 | BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2021-07-28 | — | — | EP | disclosed |
| US-10654814-B2 | Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity | KANCERA AB (SE) | 2020-05-19 | — | — | US | disclosed |
| US-20190284147-A1 | BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2019-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654814-B2 | Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity | HDAC1, HDAC11, HDAC10 | HDAC6 10/4885HDAC3 12/4885PIK3CG 2613/4885 |
| US-20190284147-A1 | BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | HDAC1, HDAC11, HDAC10 | HDAC6 10/4885HDAC3 12/4885PIK3CG 2613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.