SCHEMBL21362397

SCHEMBL21362397

CCSCc1cc(-c2cn(C)c(=O)cc2CNC(=O)OC(C)(C)C)c(C(=O)c2ccc(Cl)cc2)cn1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.35
PPARA Q07869 1/20 0.35
IDO1 P14902 2/20 0.34
PRMT5 O14744 2/20 0.34
WDR77 Q9BQA1 2/20 0.34
BRD4 O60885 5/20 0.34
ALDH1A1 P00352 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
PKM P14618 1/20 0.33
TSHR P16473 1/20 0.33
MAPT P10636 1/20 0.33
MAPK8 P45983 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 1/20 0.33
EPHX2 P34913 1/20 0.33
POLB P06746 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21362132 0.88 BRD4 (0.34) PRMT5WDR77BRD4ALDH1A1SMN1; SMN2
SCHEMBL20157810 0.81 BRD4 (0.46) PPARGPPARABRD4ALDH1A1SMN1; SMN2
SCHEMBL21362034 0.79 RAF1 (0.38) PPARGPPARAPRMT5WDR77BRD4
SCHEMBL21564746 0.79 IDO1 (0.37) PPARGPPARAIDO1PRMT5WDR77
SCHEMBL21564908 0.79 IDO1 (0.39) PPARGPPARAIDO1ALDH1A1SMN1; SMN2
SCHEMBL20157844 0.79 BRD4 (0.32) PRMT5WDR77BRD4ALDH1A1SMN1; SMN2
SCHEMBL20157351 0.78 HDAC10 (0.36) PPARGPPARABRD4ALDH1A1SMN1; SMN2
SCHEMBL21352057 0.77 BRD4 (0.34) PPARGPPARABRD4ALDH1A1SMN1; SMN2
SCHEMBL21564922 0.76 POLB (0.37) PPARGPPARAIDO1TSHRMAPK8
SCHEMBL21564753 0.75 POLB (0.38) IDO1PKMMAPK8KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3539960-A1 NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) 2019-09-18 EP disclosed