Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157492 | 0.84 | MAPT (0.57) | MAPTHTTSMN1; SMN2CNR1CNR2 | |
| SCHEMBL20157693 | 0.84 | MAPT (0.49) | MAPTHTTALDH1A1NPC1MAPK1 | |
| SCHEMBL20157692 | 0.82 | MAPK1 (0.44) | MAPTHTTALDH1A1NPC1MAPK1 | |
| SCHEMBL20157680 | 0.81 | POLB (0.42) | MAPTHTTALDH1A1NPC1MAPK1 | |
| SCHEMBL3682780 | 0.78 | MAPT (0.44) | MAPTHTTSMN1; SMN2CNR1CNR2 | |
| SCHEMBL24199843 | 0.78 | MAPT (0.51) | MAPTHTTSMN1; SMN2CNR1CNR2 | |
| SCHEMBL48235 | 0.75 | MAPT (0.52) | MAPTHTTSMN1; SMN2CNR1CNR2 | |
| SCHEMBL4844927 | 0.75 | MAPT (0.70) | MAPTHTTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL4849572 | 0.75 | RECQL (0.53) | MAPTHTTCNR1CNR2GAA | |
| SCHEMBL1552069 | 0.75 | MAPT (0.46) | MAPTHTTSMN1; SMN2CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |