SCHEMBL21363673

SCHEMBL21363673

C=CCc1cc2c(cc1OCc1cccs1)OCO2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.41
CYP3A4 P08684 3/20 0.41
CYP1A2 P05177 3/20 0.41
HTT P42858 1/20 0.39
L3MBTL1 Q9Y468 3/20 0.38
GAA P10253 1/20 0.38
POLB P06746 1/20 0.38
ALDH1A1 P00352 4/20 0.36
HPGD P15428 3/20 0.36
CLK4 Q9HAZ1 3/20 0.36
CYP2D6 P10635 3/20 0.36
TSHR P16473 3/20 0.36
MAPK1 P28482 3/20 0.36
CYP2C19 P33261 3/20 0.36
CLK1 P49759 2/20 0.36
CLK2 P49760 2/20 0.36
CLK3 P49761 2/20 0.36
DYRK1A Q13627 2/20 0.36
DYRK1B Q9Y463 2/20 0.36
CYP2C9 P11712 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14552348 0.80 MAOB (0.54) MAPTCYP3A4CYP1A2L3MBTL1GAA
SCHEMBL21363678 0.78 CDK4 (0.45) MAPTCYP3A4CYP1A2L3MBTL1POLB
SCHEMBL21363758 0.77 CYP3A4 (0.63) MAPTCYP3A4CYP1A2L3MBTL1ALDH1A1
SCHEMBL21363746 0.77 USP2 (0.44) MAPTCYP3A4CYP1A2L3MBTL1POLB
SCHEMBL21363612 0.77 HPGD (0.44) MAPTCYP3A4CYP1A2L3MBTL1ALDH1A1
SCHEMBL21363605 0.76 POLB (0.48) MAPTCYP3A4CYP1A2L3MBTL1POLB
SCHEMBL21363608 0.75 CYP3A4 (0.49) MAPTCYP3A4CYP1A2L3MBTL1POLB
SCHEMBL21363610 0.75 KMT2A (0.41) MAPTCYP3A4CYP1A2HTTL3MBTL1
SCHEMBL21363606 0.74 SLC6A4 (0.41) MAPTCYP3A4CYP1A2L3MBTL1TSHR
SCHEMBL21363609 0.73 CYP3A4 (0.48) MAPTCYP3A4CYP1A2POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019175713-A1 NEW CATECHOL MOLECULES AND THEIR USE AS INHIBITORS TO P450 RELATED METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO disclosed
WO-2019175712-A1 NEW USES FOR CATECHOL MOLECULES AS INHIBITORS TO GLUTATHIONE S-TRANSFERASE METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO disclosed