SCHEMBL21363790

SCHEMBL21363790

C=C(C)Cc1cc2c(cc1OCc1ccc3c(c1)OCO3)OCO2

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.55
KMT2A Q03164 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
PDE5A O76074 3/20 0.43
CALM1 P0DP23 3/20 0.43
CYP1A2 P05177 2/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP2C19 P33261 1/20 0.43
MAPT P10636 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
TNFRSF1A P19438 1/20 0.42
MAOB P27338 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21363607 0.87 MAOB (0.51) CYP3A4KMT2ATDP1L3MBTL1NPC1
SCHEMBL21363747 0.81 CDK4 (0.41) KMT2ATDP1L3MBTL1NPC1RAB9A
SCHEMBL11691800 0.80 CYP3A4 (0.58) CYP3A4KMT2ACALM1CYP1A2ALDH1A1
SCHEMBL21363784 0.80 MAPT (0.42) CYP3A4KMT2AL3MBTL1NPC1RAB9A
SCHEMBL21363758 0.78 CYP3A4 (0.63) CYP3A4KMT2ATDP1L3MBTL1NPC1
SCHEMBL21366582 0.77 BRS3 (0.41) L3MBTL1NPC1RAB9ACALM1ALDH1A1
SCHEMBL21363783 0.74 MAOB (0.51) KMT2ATDP1L3MBTL1NPC1RAB9A
SCHEMBL21363636 0.72 MAOB (0.59) CYP3A4KMT2ATDP1L3MBTL1NPC1
SCHEMBL8965716 0.71 CYP3A4 (0.76) CYP3A4KMT2ANPC1RAB9ACYP1A2
SCHEMBL306160 0.71 CYP3A4 (1.00) CYP3A4KMT2ANPC1RAB9ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019175713-A1 NEW CATECHOL MOLECULES AND THEIR USE AS INHIBITORS TO P450 RELATED METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO disclosed
WO-2019175712-A1 NEW USES FOR CATECHOL MOLECULES AS INHIBITORS TO GLUTATHIONE S-TRANSFERASE METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO disclosed