Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 5/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548639 | 0.93 | EPHX1 (0.44) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL25141638 | 0.91 | MAPK1 (0.42) | S1PR2S1PR4S1PR1S1PR3KDM4E | |
| SCHEMBL7067353 | 0.88 | KDM4E (0.44) | KDM4ECYP1A2CYP2D6MAPK1CYP2C19 | |
| SCHEMBL18508384 | 0.86 | KDM4E (0.44) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL24922156 | 0.85 | EPHX1 (0.50) | EPHX1CYP1A2ALDH1A1GAALMNA | |
| SCHEMBL24922153 | 0.85 | EPHX1 (0.50) | EPHX1CYP1A2ALDH1A1GAALMNA | |
| SCHEMBL24130676 | 0.85 | EPHX1 (0.50) | EPHX1CYP1A2ALDH1A1GAALMNA | |
| SCHEMBL24130543 | 0.85 | EPHX1 (0.50) | EPHX1CYP1A2ALDH1A1GAALMNA | |
| SCHEMBL6939872 | 0.85 | EPHX1 (0.50) | EPHX1CYP1A2ALDH1A1GAALMNA | |
| SCHEMBL24922151 | 0.85 | EPHX1 (0.50) | EPHX1CYP1A2ALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019177902-A1 | MODULATORS OF BTK PROTEOLYSIS AND METHODS OF USE | YALE UNIVERSITY (US) | 2019-09-19 | — | — | WO | disclosed |