Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 20/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 20/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21367269 | 0.84 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL18571880 | 0.83 | PRMT5 (0.48) | PRMT5WDR77 | |
| SCHEMBL22002265 | 0.83 | PRMT5 (0.48) | PRMT5WDR77 | |
| SCHEMBL18205053 | 0.79 | PRMT5 (0.58) | PRMT5WDR77 | |
| SCHEMBL18205106 | 0.79 | PRMT5 (0.58) | PRMT5WDR77 | |
| SCHEMBL20475716 | 0.78 | PRMT5 (0.58) | PRMT5WDR77 | |
| SCHEMBL20475713 | 0.78 | PRMT5 (0.58) | PRMT5WDR77 | |
| SCHEMBL18205040 | 0.77 | PRMT5 (0.53) | PRMT5WDR77 | |
| SCHEMBL18218380 | 0.77 | PRMT5 (0.53) | PRMT5WDR77 | |
| SCHEMBL28456179 | 0.76 | PRMT5 (0.39) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765461-B1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2019178368-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2019-09-19 | — | — | WO | disclosed |