Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24344258 | 0.85 | KLKB1 (0.85) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL19688510 | 0.84 | KLKB1 (0.69) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL31352690 | 0.84 | KLKB1 (0.78) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL31352683 | 0.84 | KLKB1 (0.78) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL26728876 | 0.84 | KLKB1 (0.70) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL21145556 | 0.82 | KLKB1 (1.00) | KLKB1 | |
| Feniralstat SCHEMBL21145564 | 0.80 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL21985907 | 0.80 | KLKB1 (0.87) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| Feniralstat SCHEMBL23456766 | 0.80 | KLKB1 (0.98) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| Sebetralstat SCHEMBL17785421 | 0.80 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021055621-A1 | PLASMA KALLIKREIN INHIBITORS AND USES THEREOF | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2021-03-25 | — | — | WO | disclosed |
| WO-2019178129-A1 | SUBSTITUTED IMIDAZOPYRIDINES AS INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2019-09-19 | — | — | WO | disclosed |