Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.68 |
| ▸ | S1PR3 | Q99500 | 17/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12000504 | 0.88 | S1PR1 (0.89) | S1PR1S1PR3CYP3A4CYP2C8KCNH2 | |
| SCHEMBL12000505 | 0.88 | S1PR1 (0.89) | S1PR1S1PR3CYP3A4CYP2C8KCNH2 | |
| SCHEMBL1812433 | 0.88 | S1PR1 (0.89) | S1PR1S1PR3CYP3A4CYP2C8KCNH2 | |
| SCHEMBL1813133 | 0.87 | S1PR1 (0.63) | S1PR1S1PR3CYP3A4CYP2C8KCNH2 | |
| SCHEMBL12000514 | 0.86 | S1PR1 (0.89) | S1PR1S1PR3CYP2C8KCNH2S1PR4 | |
| SCHEMBL12000515 | 0.86 | S1PR1 (0.89) | S1PR1S1PR3CYP2C8KCNH2S1PR4 | |
| SCHEMBL1810489 | 0.86 | S1PR1 (0.89) | S1PR1S1PR3CYP2C8KCNH2S1PR4 | |
| SCHEMBL1813155 | 0.83 | S1PR1 (0.64) | S1PR1S1PR3CYP3A4CYP2C8KCNH2 | |
| SCHEMBL21369960 | 0.83 | S1PR1 (0.75) | S1PR1S1PR3CYP3A4CYP2C8KCNH2 | |
| SCHEMBL1815203 | 0.83 | S1PR1 (0.65) | S1PR1S1PR3CYP3A4CYP2C8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2592071-B1 | Tricyclic heterocyclic compounds | BRISTOL MYERS SQUIBB CO (US) | 2019-09-18 | — | — | EP | disclosed |