Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.69 |
| ▸ | CD38 | P28907 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21369984 | 0.85 | IRAK4 (0.68) | IRAK4CD38EGFR | |
| SCHEMBL21369499 | 0.84 | IRAK4 (0.68) | IRAK4CD38EGFR | |
| SCHEMBL21369345 | 0.82 | IRAK4 (0.67) | IRAK4CD38EGFR | |
| SCHEMBL17656908 | 0.82 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL19283411 | 0.82 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL21369346 | 0.80 | IRAK4 (0.69) | IRAK4CD38EGFR | |
| SCHEMBL17209399 | 0.77 | IRAK4 (0.81) | IRAK4 | |
| SCHEMBL17209427 | 0.76 | IRAK4 (0.90) | IRAK4 | |
| SCHEMBL17259182 | 0.76 | IRAK4 (0.90) | IRAK4 | |
| SCHEMBL4357479 | 0.74 | IRAK4 (0.75) | IRAK4CD38EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200788-B1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME (US) | 2019-09-18 | — | — | EP | disclosed |