Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | CD38 | P28907 | 2/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21369343 | 0.89 | IRAK4 (0.65) | IRAK4TP53USP2LMNACYP1A2 | |
| SCHEMBL17656914 | 0.87 | IRAK4 (0.73) | IRAK4USP2LMNACYP1A2CYP3A4 | |
| SCHEMBL19283376 | 0.83 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL19283377 | 0.83 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL17656917 | 0.82 | IRAK4 (0.76) | IRAK4 | |
| SCHEMBL7714365 | 0.81 | IRAK4 (0.73) | IRAK4USP2LMNACYP1A2CYP3A4 | |
| SCHEMBL29157226 | 0.78 | IRAK4 (0.63) | IRAK4CD38HPGDSEGFR | |
| SCHEMBL6363833 | 0.78 | CD38 (0.54) | IRAK4TP53CD38HPGDSEGFR | |
| SCHEMBL4357479 | 0.78 | IRAK4 (0.75) | IRAK4USP2LMNACYP1A2CYP3A4 | |
| SCHEMBL6367334 | 0.78 | CD38 (0.54) | IRAK4TP53CD38HPGDSEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200788-B1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME (US) | 2019-09-18 | — | — | EP | disclosed |